Historically, our lab has been interested in calcium (Ca2+), its homeostasis, and its role in cell signalling, both in health and disease.
Our research activity is mainly aimed at unravelling the intricacies of cellular calcium (Ca2+) signalling, both in health and disease, with special incidence on organelle Ca2+ handling and function. By combining biochemistry, molecular biology and imaging/electrophysiology approaches, both in vitro and in vivo, we investigate specific Ca2+ signalling pathways in normal and pathological conditions.
We are particularly interested in identifying specific Ca2+ alterations in different neurodegenerative disorders. To this end, we continue to carry out detailed analyses of various aspects of Ca2+ signalling in Alzheimer's Disease (AD) and Hereditary Spastic Paraplegia. In the former, we exploit different AD mouse models, while in the latter we use Drosophila melanogaster as a model organism.
To address our research goals, we regularly generate state-of-the-art bespoke biosensors, both for Ca2+ and other ions and metabolites. To finely dissect intracellular variations, our biosensors are generally targetted to specific subcellular locations, such as the endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, peroxisomes, and plasma membrane. These tools are instrumental for determining a high-resolution map of the heterogeneity of signalling pathways within the cell.
Our lab is also part of the Advanced Light Microscopy Italian Node of Euro-BioImaging.
Euro-BioImaging is a European network that offers life scientists access to imaging instruments, expertise, training opportunities and data management services, regardless of their affiliation, area of expertise or field of activity. These pan-European open access services are provided with high quality standards by leading imaging facilities and it is with pride that we offer our contribution to this innovative framework.
The Research section of this website contains additional information regarding current projects, as well as a comprehensive list of research papers that reflect our scientific activity.
The work carried out in our lab over the years relies on the continued support from various funding entities, which we gratefully acknowledge.
For details on currently active grants sustaining our current research lines, please see the Research section.
We're on the cover of cells!
Check out Rigotto et al..
We are honoured and grateful: Cure Alzheimer's Fund has funded our project entitled "Extracellular ATP is a key factor in promoting Alzheimer's disease neuroinflammation". Thank you.