Ca2+ Signalling Lab
calcium mitochondria cell signalling presenilins indicators Drosophila

Welcome to the Pizzo Lab website. Our lab is located in the Vallisneri Biology Complex, a multi-department research centre of the University of Padua; we are part of the Department of Biomedical Sciences.

Historically, our lab has been interested in calcium (Ca2+), its homeostasis, and its role in cell signalling, both in health and disease.

Our research activity is mainly aimed at unravelling the intricacies of cellular calcium (Ca2+) signalling, both in health and disease, with special incidence on organelle Ca2+ handling and function. By combining biochemistry, molecular biology and imaging/electrophysiology approaches, both in vitro and in vivo, we investigate specific Ca2+ signalling pathways in normal and pathological conditions.

We are particularly interested in identifying specific Ca2+ alterations in different neurodegenerative disorders. To this end, we continue to carry out detailed analyses of various aspects of Ca2+ signalling in Alzheimer's Disease (AD) and Hereditary Spastic Paraplegia. In the former, we exploit different AD mouse models, while in the latter we use Drosophila melanogaster as a model organism.

To address our research goals, we regularly generate state-of-the-art bespoke biosensors, both for Ca2+ and other ions and metabolites. To finely dissect intracellular variations, our biosensors are generally targeted to specific subcellular locations, such as the endoplasmic reticulum, Golgi apparatus, mitochondria, nucleus, peroxisomes, and plasma membrane. These tools are instrumental for determining a high-resolution map of the heterogeneity of signalling pathways within the cell.

Our lab is also part of the Advanced Light Microscopy Italian Node of Euro-BioImaging. Euro-BioImaging is a European network that offers life scientists access to imaging instruments, expertise, training opportunities and data management services, regardless of their affiliation, area of expertise or field of activity. These pan-European open access services are provided with high quality standards by leading imaging facilities and it is with pride that we offer our contribution to this innovative framework.

The Research section of this website contains additional information regarding current projects, as well as a comprehensive list of research papers that reflect our scientific activity.


The work carried out in our lab over the years relies on the continued support from various funding entities, which we gratefully acknowledge.

Logo: Alzheimer's Association
Chan Zuckerberg Initiative
Cure Alzheimer's Fund
University of Padua

For details on currently active grants sustaining our current research lines, please see the Research section.

UniPD Logo 800 years
DSB logo

Latest lab news

Our very own Michaela Rossini got her Ph.D.
Congratulations from all of us and best wishes for the future!

Our very own Sonia Sonda represented our department in this year's Three-minute Thesis Competition!

3MT 2024 flyer

Flyer »»»
See also the gallery.

Check out our Brain Awareness Week gallery

Check out our contribution
to this year's
Brain Awareness Week

BAW 2024 flyer

Flyer »»»
See also the BAW website.

We're on the cover of

cells cover

Check out Rigotto et al. DOI logo.

We're on the cover of
Cell Calcium!

Cell Calcium cover

Check out the special issue on Mitochondria: Function and disease curated by Paola Pizzo DOI logo and our reviews by Filadi and Greotti DOI logo and Di Benedetto et al. DOI logo.

We're on the cover of
Trends in Neurosciences!

TINS cover

Check out Plotegher et al. DOI logo and the cover credits.

We're on the cover of
The FEBS Journal!

FEBS cover

Check out our State-of-the-Art Review, Rossini et al DOI logo.